The Best Flea Medicine for Dogs

Fleas bites are no fun for you or your dog, and it’s important to take measures to protect your pet against these stubborn pests. Flea medicine for dogs is a great solution for year-round pest protection. That’s why many pet parents rely on it to prevent an infestation that can cause serious health problems for pets and people.

We reviewed dozens of flea medicines to identify the best of the best, based on factors including Amazon reviews, affordability, convenience, and performance. We then narrowed down our search to 5 of the top-rated flea medicines for dogs that will protect your pet against parasites.

Top Pick
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Bayer K9 Advantix II Extra Large Dog

A popular and effective flea medicine that’s perfect for extra large dogs.

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$67.99 USD

We’ve identified Bayer K9 Advantix II Extra Large Dog as our top pick of flea medicines for dogs. Suitable for extra large dogs, it’s veterinarian-recommended, waterproof, and formulated to kill fleas at all life stages.

The 5 Top-Rated Flea Medicines for Dogs

Editor's PicksBrandRating
Best OverallBayer K9 Advantix II Extra Large Dog3.6
Runner UpFrontline Plus for Dogs Large Dog3.4
Best Budget BuyAdvecta II Flea Treatment3.7
Best Oral Flea Medicine for DogsNovartis Capstar Flea Tablets for Dogs and Cats3.8
Best Topical Flea Medicine for DogsFrontline Plus for Dogs Small Dog3.3

*Ratings are from Amazon at the time of publication and can change

Our Top Pick: Bayer K9 Advantix II Extra Large Dog

Bayer k9 Advantix II Extra Large Dog is a reliable, veterinarian-recommended flea medicine that’s powerful enough to repel and kill fleas, ticks, and mosquitoes on extra large dogs. It is also convenient to use, and kills fleas within 10 minutes of application.

This flea medicine stood out to us because it kills a wide variety of parasites through contact with no biting required. This means that your pet is protected from irritation and deadly diseases that can be transmitted by pest bites. Reviewers say Bayer K9 Advantix II Extra Large Dog is highly effective, affordable, and easy to apply.

Bayer K9 Advantix II Extra Large Dog Key Features: 

  • Veterinarian-recommended
  • Kills fleas, ticks, and mosquitoes through contact
  • Kills fleas at all life stages
  • Waterproof
  • Easy to apply

Our Runner Up Pick: Frontline Plus for Dogs Large Dog

Runner Up
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Frontline Plus for Dogs Large Dog

Long-lasting flea and tick medicine for large dogs.

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$64.00 USD

Frontline Plus for Dogs Large Dog is a waterproof flea and tick treatment with a fast-acting, long-lasting formula that kills fleas and ticks at all life stages. The product is designed for use on dogs 45-88lb., and gives non-stop flea and tick protection for a full 30 days.

Frontline Plus for Dogs is a proven flea and tick medicine that has been trusted by veterinarians for nearly 20 years. This product is a good choice for pet parents looking for a reliable flea medicine from an established market leader.

Frontline Plus for Dogs Large Dog Key Features: 

  • Waterproof flea and tick treatment
  • 30-day protection
  • Fast-acting, long-lasting formula
  • Trusted by veterinarians

Best Budget Pick: Advecta II Flea Treatment

Best for Budget
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Advecta II Flea Treatment

An effective flea medicine for dogs with a budget-friendly price.

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$19.99 USD

Advecta II Flea Treatment is a budget-friendly alternative to the leading brands that contains the same powerful active ingredients. The waterproof, fragrance-free formula kills fleas and lice within 12 hours of application, and prevents reinfestations for up to 4 months.

The convenient, easy-to-apply topical solution kills fleas at all life stages. Many reviewers say the product works just as well as more expensive brands and can be relied upon to kill fleas and lice.

Advecta II Flea Treatment Key Features: 

  • Affordable price
  • Kills fleas and lice within 12 hours of application
  • Contains the same active ingredients as leading brands
  • Waterproof and fragrance-free formula

Best Oral Flea Medicine for Dogs: Novartis Capstar Flea Tablets for Dogs and Cats

Best Oral Flea Medicine for Dogs
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Novartis Capstar Flea Tablets for Dogs and Cats

A single-dose oral flea treatment for household pets.

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$32.99 USD

If you’re looking for an oral flea medicine from a trusted brand, Novartis Capstar Flea Tablets for Dogs and Cats are an excellent choice. The single-dose tablets kill fleas on dogs within 4 hours of application, and can be easily administered by placing the pill directly in your pet’s mouth or hiding it in food.

This product is great for dealing with an infestation, and is safe for use in dogs, puppies, cats, and kittens that are at least 4 weeks old and weigh 2lb. or over.

Novartis Capstar Flea Tablets for Dogs and Cats Key Features: 

  • Kill fleas fast
  • Easy to administer
  • Single-dose treatment
  • Suitable for dogs and cats

Best Topical Flea Medicine for Dogs: Frontline Plus for Dogs Small Dog

Best Topical Flea Medicine for Dogs
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Frontline Plus for Dogs Small Dog

A safe and effective topical flea medicine for small dogs.

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$34.99 USD

If you’re the proud pet parent of a small dog, Frontline Plus for Dogs Small Dog is the perfect solution for keeping pests at bay. The long-lasting, waterproof formula kills parasites fast, and works non-stop for a full 30 days.

This product is designed for use on dogs 5-22 lbs. It can be relied upon to kill fleas, flea eggs, lice, and ticks and prevent the establishment of new infestations.

Frontline Plus for Dogs Small Dog Key Features: 

  • Works non-stop for 30 days
  • Easy-to-use topical formula
  • Kills pests fast
  • Waterproof

Who Should Buy Flea Medicine for Dogs

Administering flea medicine for dogs is a safe, effective, and convenient way to repel and kill fleas and other parasites. A flea infestation in your home can lead to severe discomfort for pets and people. Flea bites can also endanger your dog’s health by causing conditions such as anemia and spreading diseases including Flea Allergy Dermatitis (FAD) and Bartonella.

For these reasons, it’s important that every pet parent takes measures to protect their dog from fleas. If you’d like more information about flea control, check out our article, How Can I Get Rid Of Fleas On My Dogs?

Top Pick
Buy Now
Bayer K9 Advantix II Extra Large Dog

A popular and effective flea medicine that’s perfect for extra large dogs.

buy now
$67.99 USD

Important Features to Consider

Flea medicine for dogs should have a few important features. Here’s what to consider when selecting flea medicine to protect your pet against stubborn pests.

Oral or topical treatments. There are two main types of flea medicines for dogs; oral and topical treatments. Oral treatments are usually given in the form of a tablet, and contain insecticides that travel into your dog’s bloodstream. When fleas bite your dog they ingest the insecticide and die. Oral treatments typically only last for around 24 hours, and are best for rapidly controlling an infestation. Topical treatments are concentrated liquid formulas that are applied to your dog’s skin. They take longer to work, but unlike oral medications, they protect your pet against fleas at all life stages for up to a month.

Protection period. Always read the manufacturer’s product information to check the protection period of the flea medicine and how often to administer it. As stated above, oral treatments provide short-term protection while topical treatments will protect your pet for up to a month.

Waterproof. If you decide on a topical treatment, consider choosing a product that’s waterproof. This will help ensure that the flea medicine stays effective for as long as possible.

Protection against other parasites. Some flea medicines kill other parasites such as ticks, lice, and mosquitoes. These products can be an excellent choice for pet parents looking for a complete pest control solution.

Safety and effectiveness. Before purchasing flea medicine for your dog, do some research to find out which products are the safest and most effective at killing fleas and other parasites. The best way to do this is by looking at the manufacturer’s product information to identify the active ingredients. You can then research the ingredients online to find out more them. Amazon reviews can also be a good source of information on the safety and effectiveness of flea medicine products.

Frequently Asked Questions

What is dog flea medicine and how does it work?

Dog flea medicine is used to repel and kill fleas and other parasites. It contains chemical or plant-based insecticides and repellants that kill adult fleas, eggs, and larvae. Oral treatments enter the bloodstream and kill fleas when your pet is bitten. Topical treatments are absorbed into your pet’s oil glands and spread over the body to eliminate pests.

Should I choose an oral or topical dog flea medicine?

Oral dog flea medicine is the best solution for rapidly killing fleas and controlling an infestation, while topical dog flea medicine is ideal for long-term protection against fleas and other parasites.

Can you use vinegar to get rid of fleas on a dog? 

Yes. Vinegar is a natural product that can help get rid of fleas on dogs. It contains ascetic acid which has a strong smell and taste that fleas avoid. Please be aware that vinegar is best used as a flea preventative for pets and may be less effective than commercial products.

Does baking soda kill fleas on dogs?

Yes. Baking soda mixed with table salt is a natural home remedy that can be used to eliminate fleas. It works by dehydrating fleas and their eggs, leading to their death. Baking soda and salt is most effective at killing fleas when applied to infested carpets and furniture.

Other Flea Medicines for Dogs We Reviewed

Top Pick
Buy Now
Bayer K9 Advantix II Extra Large Dog

A popular and effective flea medicine that’s perfect for extra large dogs.

buy now
$67.99 USD

We looked at 20 other flea medicines for dogs. Even though they didn’t make our 5 best flea medicines for dogs list, they’re the best of the rest and each is still a great option for controlling pests. The information you’ll need to compare each one is included with the listing.

Oral Flea Medicine for Dogs

PetArmor FastCaps

PetArmor FastCaps

A safe and effective oral flea medicine for dogs. The easy-to-dose tablets begin killing fleas in just 30 minutes.

Key Features: 

  • Single-dose tablets
  • Begin working within 30 minutes
  • Contains the veterinarian-recommended active ingredient nitenpyram
  • Suitable for dogs over 25lbs.

Cost: $22

SENTRY Capguard Oral Flea Control Medication

SENTRY Capguard Oral Flea Control Medication

A reliable oral flea medicine that contains nitenpyram, an active ingredient that’s recommended by veterinarians for controlling flea infestations.

Key Features: 

  • Easy-to-dose tablet format
  • Starts working in 30 minutes
  • Kills adult fleas on your pet
  • Contains nitenpyram
  • For dogs and cats 2-25lbs.

Cost: $26

Topical Flea Medicine for Dogs

Adventure Plus for Dogs

Adventure Plus for Dogs

This flea medicine from Adventure Plus is suitable for dogs 11-20 lbs. It offers triple flea protection; killing adult fleas, larvae, and eggs.

Key Features: 

  • Starts working on contact
  • Waterproof
  • Kill fleas at all life stages
  • For dogs 11-20 lbs.

Cost: $28

Bayer Advantage II Topical Flea Treatment

Bayer Advantage II Topical Flea Treatment

A topical treatment for dogs that kills multiple flea life stages and protects your pet for a full 30 days.

Key Features: 

  • Starts working within 12 hours
  • Kills multiple flea life stages through contact
  • Protects pets for 30 days
  • Odorless and waterproof
  • Available for small to extra large dogs

Cost: $43

Bayer K9 Advantix II Large Dog

Bayer K9 Advantix II Large Dog

A once-a-month topical flea medicine for large dogs that kills 98-100% of fleas within 12 hours of application.

Key Features: 

  • Once-a-month treatment
  • Package contains 6 applications for 6 months of protection
  • Kills 98-100% of fleas within 12 hours
  • Water-resistant

Cost: $82

CrossBlock II Flea Preventative for Dogs

CrossBlock II Flea Preventative for Dogs

An affordable topical flea medicine for dogs. This product contains 3 monthly doses for dogs 55 lbs. and over.

Key Features: 

  • Affordable, generic version of the popular Advantage II flea medicine for dogs
  • Kills adult fleas and prevents further re-infestation
  • Waterproof
  • Effective for 1 month
  • Suitable for dogs 55lbs. and over.

Cost: $20

Direct Protect Plus Flea & Tick Topical for Dogs

Direct Protect Plus Flea & Tick Topical for Dogs

An inexpensive flea medicine for dogs that contains the same active ingredients found in Frontline Plus For Dogs.

Key Features: 

  • Kills fleas, ticks, lice, and mosquitoes
  • Starts killing fleas and ticks within 4 hours
  • Waterproof after 12 hours
  • 3-month supply
  • Available for different sizes of dog

Cost: $23

Frontline Plus for Dogs Medium Dog

Frontline Plus for Dogs Medium Dog

A waterproof flea and tick medicine for medium size dogs from the popular and reliable Frontline Plus range.

Key Features: 

  • 30-day protection
  • Breaks the flea life cycle
  • Kills fleas and ticks
  • Suitable for use on dogs 23-44 lbs.

Cost: $66

Frontline Plus for Dogs Extra Large Dog

Frontline Plus for Dogs Extra Large Dog

Looking for an effective flea medicine to protect your extra large dog? This product from Frontline is an excellent choice.

Key Features: 

  • Kills fleas, flea eggs, lice, and ticks
  • Fast-acting
  • Protects your pet for a full 30 days
  • Waterproof
  • For dogs 89-132 lbs.

Cost: $30

PetArmor Flea & Tick Treatment for Large Dogs

PetArmor Flea & Tick Treatment for Large Dogs

A fast-acting, long-lasting topical flea medicine for large dogs that begins working in as little as an hour and protects your pet for 30 days.

Key Features: 

  • Kills fleas, ticks, and lice
  • Waterproof
  • 3-month supply
  • Suitable for dogs 45-88 lbs.

Cost: $26

PetArmor Flea & Tick Treatment for Small Dogs

PetArmor Flea & Tick Treatment for Small Dogs

This fast-acting flea medicine from PetArmor offers long-lasting protection for small dogs against fleas, ticks, and lice.

Key Features: 

  • Kills fleas, ticks, and lice
  • Begins working in as little as an hour
  • Waterproof
  • Suitable for dogs 5-22 lbs.

Cost: $27

PetArmor 6 Count Plus for Dogs Flea and Tick Squeeze-On

PetArmor 6 Count Plus for Dogs Flea and Tick Squeeze-On

This value pack from PetArmor contains a 6-month supply of topical flea medicine for medium size dogs.

Key Features: 

  • Kills fleas, flea eggs, flea larvae, ticks, and lice
  • Starts killing fleas and ticks within 24 hours
  • Waterproof
  • 6-month supply
  • Suitable for dogs 23-44 lbs.

Cost: $40

Sentry FiproGuard Topical Flea and Tick for Dogs

Sentry FiproGuard Topical Flea and Tick for Dogs

A long-lasting and effective flea and tick medicine for dogs that contains the powerful active ingredient, fipronil.

Key Features: 

  • Delivers protection against fleas, ticks, and lice
  • Waterproof
  • 30-day protection
  • Available for different sizes of dog

Cost: $20-$23

TevraPet Activate II Flea and Tick Topical

TevraPet Activate II Flea and Tick Topical

A vet quality flea medicine for small to extra large dogs that repels and kills fleas, flea eggs, ticks, mosquitoes, and lice for up to 30 days.

Key Features: 

  • 30-day protection
  • Contains powerful and effective active ingredients
  • Easy-to-apply
  • 4-month supply

Cost: $24-$27

Vectra 3D Purple for Dogs

Vectra 3D Purple for Dogs

A long-lasting, convenient topical treatment for large dogs that kills fleas on contact and offers broad spectrum protection.

Key Features: 

  • Fast-acting medicine kills fleas in 6 hours
  • Monthly dose repels and kills fleas, ticks, mosquitoes, biting and sand flies, lice, and mites
  • Stops flea infestation and prevents re-infestation
  • Waterproof
  • Suitable for dogs 56-95 lbs.
  • 6 doses included

Cost: $65

Natural Topical Flea Medicine for Dogs

Arava Natural Flea & Tick Prevention for Dogs

Arava Natural Flea & Tick Prevention for Dogs

This natural topical flea and tick medicine for dogs from Arava utilizes aromatherapy essential oils to eliminate pests. It is 100% chemical-free and FDA-approved.

Key Features: 

  • Safe and effective formula contains 11 active botanical ingredients to eliminate fleas and ticks
  • Kills and repels pests
  • Easy application
  • Suitable for small, medium, and large size dogs

Cost: $34

Dr. Mercola Spot On Topical Herbal Flea & Tick Repellent for Dogs

Dr. Mercola Spot On Topical Herbal Flea & Tick Repellent for Dogs

A safe and natural topical flea medicine for dogs that contains a blend of essential oils. This product repels ticks and fleas by masking your dog’s scent.

Key Features: 

  • No synthetic chemicals
  • Effective and safe
  • Offers long-term protection against fleas and ticks
  • 3-month supply

Cost: $20

Ecolife All Natural Flea And Tick Spot-On Treatment For Dogs and Puppies

Ecolife All Natural Flea And Tick Spot-On Treatment For Dogs and Puppies

An all-natural, safe, and non-toxic spot-on topical flea medicine for dogs that’s suitable for repelling and killing fleas and other pests on dogs of all sizes.

Key Features: 

  • 4-month supply
  • Safe and non-toxic
  • Waterproof
  • Easy-to-use design

Cost: $10

Terra Pet Naturals 100% Natural Flea and Tick Repellent for Dogs

Terra Pet Naturals 100% Natural Flea and Tick Repellent for Dogs

An easy-to-apply flea medicine for dogs made from a blend of natural essential oils that repels fleas and ticks without the use of chemicals.

Key Features: 

  • All-natural protection from fleas and ticks
  • Safe and non-toxic
  • Designed to last for several months

Cost: $23

Vet’s Best Flea and Tick Spot-on Drops Topical Treatment for Dogs

Vet's Best Flea and Tick Spot-on Drops Topical Treatment for Dogs

A natural topical flea medicine for large dogs made with a unique blend of certified natural oils including clove, thyme, and cinnamon oils.

Key Features: 

  • 4-month supply
  • Kills and repels fleas and ticks
  • Independently tested and proven effective
  • Made with natural oils
  • Suitable for dogs over 40 lbs.

Cost: $13

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