The Best Dog Toothpastes

Keeping your dog’s teeth and gums healthy is an important part of dog ownership. Failing to brush can lead to gum disease, tooth loss, and even more serious issues. But, picking out the best dog toothpaste isn’t as simple as it sounds. There are all kinds of dog toothpaste available, which might leave you wondering which is right for your four-legged friend and whether she can just use your human toothpaste (she can’t!). To keep your dog’s smelly breath at bay, you’ll also want to check out our review of the best dog breath sprays.

We reviewed dozens of dog toothpastes to identify the best of the best. We focused on a range of features, such as cleaning power, tube size, flavor, palatablity, cost, and average customer reviews. 

Top Pick

This highly-effective toothpaste doesn’t come cheap but does its job well

After some extensive research, Enzadent 3 Pack Enzymatic Toothpaste for Dogs and Cats stood out as the very best in dog toothpaste. The palatable poultry flavor makes dogs happy about having their teeth brushed and the enzymatic formula is excellent at removing plaque.

The 5 Top-Rated Dog Toothpastes

Editor's PicksBrandRating
Best OverallEnzadent 3 Pack Enzymatic Toothpaste for Dogs and Cats4.7
Runner UpVirbac C.E.T. Enzymatic Toothpaste4.5
Best Budget BuyPetrodex Enzymatic Toothpaste Dog Poultry Flavor4.5
Best Toothpaste for PuppiesArm & Hammer Dog Dental Care Toothpaste4.3
Best Organic Dog ToothpasteAndy Anand Organic Enzymatic Toothpaste for Pets 4.0

*Ratings are from Amazon at the time of publication and can change

Our Top Pick: Enzadent 3 Pack Enzymatic Toothpaste for Dogs and Cats

When it comes to looking after your dog’s dental health, you don’t want to cut corners. Enzadent 3 Pack Enzymatic Toothpaste for Dogs and Cats is a product you can rely on to do a good job keeping your canine companion’s teeth clean.

Retailing at around $30, it’s the most expensive option on our list, but you do get three 3.2-ounce tubes for your money, so the price is more affordable than it appears at first glance. More importantly, it’s a toothpaste you know will work. The triple enzyme system is highly effective at removing plaque and polishing your dog’s teeth, so regular brushing will help prevent, or even reverse, gum disease.

This toothpaste is poultry flavored and contains real poultry extract, which helps to make it tasty enough to tempt your four-legged friend. Since this is a non-foaming formula, it’s safe for your poet to swallow and there’s no need to rinse, making tooth-brushing time a breeze.

Enzadent 3 Pack Enzymatic Toothpaste for Dogs and Cats Key Features: 

  • Palatable poultry flavor
  • Triple enzyme formula
  • Made in the USA

Our Runner Up Pick: Virbac C.E.T. Enzymatic Toothpaste

Runner Up
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Virbac C.E.T. Enzymatic Toothpaste

With a range of flavors available, you’re sure to find one your dog loves

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$9.99 USD

If our top pick doesn’t take your fancy, our runner up choice, Virbac C.E.T. Enzymatic Toothpaste, is also an excellent option. It comes in four flavors: poultry, beef, malt, and seafood, so there’s bound to be an option that even a picky pooch will like the taste of.

Like our top pick, this doggy toothpaste contains enzymes that help break down plaque and keep your pup’s teeth and gums healthy and his breath fresh. Not only that, but Virbac C.E.T. has a natural antibacterial action that aids in preventing the buildup of plaque.

Without foaming agents, this pet toothpaste is safe for your pet to swallow and requires no rinsing. While not all dogs take to having their teeth brushed, most users report their pets enjoying the taste, which can go a long way when convincing your pooch to open wide.

Depending on the flavor you select, this toothpaste costs anywhere between $7 and $15 for a 2.5-ounce tube.

Virbac C.E.T. Enzymatic Toothpaste Key Features: 

  • Removes and prevents plaque
  • Four flavor options
  • No foaming agents

Best Budget Pick: Sentry Petrodex Enzymatic Toothpaste Dog Poultry Flavor

Best for Budget
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Sentry Petrodex Enzymatic Toothpaste Dog Poultry Flavor

You get a lot of bang for your buck and exceptional performance with Petrodex Enzymatic Toothpaste

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$9.12 USD

Extremely popular and highly affordable, Sentry Petrodex Enzymatic Toothpaste Dog Poultry Flavor is the perfect choice for anyone looking to save a few bucks. Costing $7 for a 6.2-ounce tube, it’s the same price as the cheapest flavor of our runner up pick, but you get more than twice the amount in each tube, so it works out far more affordable.

If you’re not expecting great performance from such an inexpensive dog toothpaste, you’ll be pleasantly surprised! With more than 1,75- 4- and 5-star reviews on Amazon, this isn’t some ineffective budget buy, it’s the real deal. The enzymatic formula helps to remove even stuck on plaque and tartar, as well as freshening breath.

While it only comes in one flavor, poultry, it seems to be palatable to the vast majority of dogs. While Sentry recommends brushing with their own brand Petrodex toothbrush, any soft-bristled toothbrush, or even a finger brush, will get the job done.

Sentry Petrodex Enzymatic Toothpaste Dog Poultry Flavor Key Features: 

  • Tasty poultry flavor
  • Cleans with the help of enzymes
  • Aids in fighting canine gum disease

Best Toothpaste for Puppies: Arm & Hammer Dog Dental Care Toothpaste

Best for Puppies
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Arm & Hammer Dog Dental Care Toothpaste

This gentle formula is completely safe for puppies’ teeth

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$6.49 USD

It’s never too early to start brushing your dog’s teeth, but you need to choose the right toothpaste for young mouths. While it’s not specifically designed for puppies, Arm & Hammer Dog Dental Care Toothpaste is made with a gentle enough formula that it’s suitable for dogs of over 8 weeks old. While we’re focusing on the chicken flavor Gum Health formula, you can also find Fresh Breath and Tartar control formulas in beef and vanilla-ginger flavors.

This toothpaste is made using predominately natural ingredients, with the cleaning power of baking soda, as well as enzymes to break down plaque. A range of herbs in this formula are designed to soothe gums, which is an additional bonus for teething puppies. The majority of users report excellent results from this canine toothpaste, stating it reduces plaque buildup, whitens teeth, and freshens breath.

With a retail price around $6 for a 2.5-ounce tube, it costs more than some options, ounce for ounce, but is still very reasonably priced.

Arm & Hammer Dog Dental Care Toothpaste Key Features: 

  • Enzymatic formula
  • Utilizes the cleaning power of baking soda
  • Gentle enough for puppies

Best Organic Dog Toothpaste: Andy Anand Organic Enzymatic Toothpaste for Pets

Best Organic
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Andy Anand Organic Enzymatic Toothpaste for Pets

A natural and organic option for eco-conscious pet parents

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If you prefer to use organic products where possible, we’d recommend Andy Anand Organic Enzymatic Toothpaste for Pets. Despite its all-natural ingredients, this toothpaste stands up well to the alternatives. It might not be quite as effective at removing tough tartar buildups, but it helps prevent new plaque from forming on the teeth.

The main active ingredients are neem, baking soda, and coconut oil, but this formula also contains enzymes that are highly effective at removing plaque. It changed the pH of your dog’s mouth, making it inhospitable to the bacteria that cause plaque and gum disease. With ingredients such as mint and clove oil, it will leave your pet’s breath fresh, but not all dogs find it as palatable as more traditional meaty flavors.

Even with it’s organic and all-natural credentials, this toothpaste costs just $6 for a 2.5-ounce tube, so it certainly won’t break the bank.

Andy Anand Organic Enzymatic Toothpaste for Pets Key Features: 

  • Organic formula
  • Fresh flavor
  • Contains beneficial herbs

Who Should Buy Dog Toothpaste

Everyone who owns a dog should buy dog toothpaste. Dental health is important to your dog’s overall well-being. Poor dental hygiene can lead to gum disease, sore teeth and gums, tooth loss, and even systemic infections, in more extreme cases. Taking good care of your dog’s teeth throughout her life will stand her in good stead in old age, when tooth pain and tooth loss can lead to difficulties eating.

Even if your four-legged friend won’t put up with having his teeth brushed, you should still buy dog toothpaste. You may be able to gradually desensitize him to having his teeth brushed. Otherwise, there are some canine toothpastes that still work (albeit slightly less effectively) if you rub them on the gums or even just get them in his mouth.

Top Pick

This highly-effective toothpaste doesn’t come cheap but does its job well

Important Features to Consider

Dog toothpaste should have a few important features. Here’s what to consider when selecting toothpaste for your dog:

  • Cleaning power. The most important thing about a dog toothpaste is that it works! It should be powerful enough to remove bacteria and plaque before it hardens. The best formulas can even remove caked on tartar, which is good news if you’re starting an oral hygiene routine for your dog, but have been lax in the past.
  • Enzymes. Many modern dog toothpastes contain enzymes. We’ll discuss the benefits of enzymatic toothpastes in more detail below, but they tend to be more effective at both removing and preventing plaque.
  • Foaming agent-free. While this is true for the vast majority of dog toothpastes, you should make sure the option you choose is free from foaming agents. This means it’s safe for your pet to swallow and doesn’t require rinsing, which is no mean feat.
  • Flavor and palatability. Dog toothpaste comes in various flavors, and not all of it is equally tasty. Choosing a palatable canine toothpaste is important, especially if your dog is reluctant to have his teeth brushed, anyway. A bad-tasting toothpaste will only make it more of an ordeal.
  • Tube size. If you’re trying to compare prices, make sure you factor in the tube size. Toothpaste A might cost a dollar more than Toothpaste B, but if A comes in a 5-ounce tube and B comes in a 2.5-ounce tube, A offers better value for money.

Frequently Asked Questions

What is the difference between dog toothpaste and human toothpaste?

The main difference between dog toothpaste and human toothpaste is that the doggy version is designed to be swallowed and the human version isn’t. Human toothpaste often contains certain ingredients that are toxic to dogs, such as the sweetener xylitol, which is why you should never use human toothpaste to brush your pooch’s teeth.

What is enzymatic toothpaste for dogs?

Enzymatic toothpaste for dogs contains either just the enzyme glucose oxidase (GOx) or both GOx and lactoperoxidase (LPO). When exposed to glucose and oxygen, GOx becomes antibacterial, generating hydrogen peroxide that helps remove plaque and tartar. LPO is activated by the hydrogen peroxide and also targets plaque. Because of the way the enzymes work, they only need to come into contact with the teeth to start working, which is ideal if your four-legged friend resists extended tooth-brushing sessions.

When should you start brushing your dog’s teeth?

Once you get your puppy home, it’s never too early to get her into a good brushing routine. Ideally, you should start between the ages of 8 and 16 weeks to get her acclimated to the process early and make your job easier when she reaches adulthood. Start slowly, however, with plenty of praise and treats, so as not to put her off.

How often should you brush your dog’s teeth?

Ideally, you should brush your dog’s teeth daily, but if you can’t commit to that, every other day will do.

Other Dog Toothpaste We Reviewed

Top Pick

This highly-effective toothpaste doesn’t come cheap but does its job well

We looked at 20 other dog toothpastes. Even though they didn’t make our 5 best dog toothpastes list, they’re the best of the rest and each is still a great option for your canine companion. The information you’ll need to compare each one is included with the listing.

Enzymatic Dog Toothpaste

Arm & Hammer Advanced Care Tartar Control Enzymatic Toothpaste

Arm & Hammer Advanced Care Tartar Control Enzymatic Toothpaste

A palatable beef-flavored toothpaste that uses the combined powers of enzymes and baking soda to control tartar on your dog’s teeth.

Key Features: 

  • Cleans teeth and freshens breath
  • Beef flavor
  • 2.5-ounce tube

Cost: $13

C.E.T. Vanilla-Mint Pet Toothpaste

C.E.T. Vanilla-Mint Pet Toothpaste

With its dual enzyme system, this dog toothpaste will control plaque and tartar on your dog’s teeth while leaving his breath minty-fresh.

Key Features: 

  • Vanilla-mint flavor
  • Great for sensitive teeth
  • 2.5-ounce tube

Cost: $15

Nutri-Vet Toothpaste for Dogs

Nutri-Vet Toothpaste for Dogs

Like other enzymatic formulas, this toothpaste kills bacteria in the mouth and helps to break down plaque. The chicken flavor is palatable to most dogs.

Key Features:

  • Comes in a 2.5-ounce tube
  • Polishes teeth
  • Freshens breath

Cost: $13

Sentry Petrodex Enzymatic Toothpaste

Sentry Petrodex Enzymatic Toothpaste

Sold as a pack of two, this highly-effective enzymatic canine toothpaste offers great value for money and will taste great to your dog.

Key Features: 

  • Two tubes of 6.2 ounces
  • Poultry flavor
  • Controls plaque effectively

Cost: $20

Vetoquinol Enzymatic Toothpaste for Dogs & Cats

Vetoquinol Enzymatic Toothpaste for Dogs & Cats

If you want to clean your dog’s teeth like a pro, this veterinary-grade enzymatic pet toothpaste is an excellent choice.

Key Features: 

  • Fights plaque and tartar
  • Palatable poultry flavor
  • 3.2-ounce tube

Cost: $15

Vet’s Best Dog Enzymatic Toothpaste and Toothbrush

Vet's Best Dog Enzymatic Toothpaste and Toothbrush

With this dental care kit, you get a quality enzymatic doggy toothpaste, along with a specially designed toothbrush; everything you need to get started.

Key Features: 

  • Triple-headed toothbrush cleans from all angles
  • Quality enzymatic toothpaste with baking soda
  • 3.5 ounce tube of toothpaste and brush included

Cost: $15

Vet’s Best Enzymatic Dog Toothpaste

Vet’s Best Enzymatic Dog Toothpaste

If you like the look of the toothpaste above, but you don’t require a toothbrush, this is a better, more affordable, option.

Key Features: 

  • Gently cleans plaque and tartar
  • Inspired by nature with aloe, neem oil, and baking soda
  • 3,5-ounce tube

Cost: $5

Vets Preferred Advanced Enzymatic Toothpaste for Dogs

Vets Preferred Advanced Enzymatic Toothpaste for Dogs

Palatable peanut butter flavor dog toothpaste with veterinarian-grade enzymatic cleaning action, and made in the USA to boot!

Key Features: 

  • Tasty peanut butter flavor
  • Tough on plaque
  • 3-ounce package size

Cost: $13

Natural Dog Toothpaste

ECOLAND Natural Organic Dog and Cat Toothpaste

ECOLAND Natural Organic Dog and Cat Toothpaste

Use a range of natural ingredients, such as aloe; rosemary extract; and green tea extract, to naturally fight plaque and freshen breath.

Key Features: 

  • Comes in a 2.8-ounce tube
  • Helps remove plaque
  • Two finger toothbrushes included

Cost: $16

HDP EZ Toothpaste for Dogs

HDP EZ Toothpaste for Dogs

Some dogs don’t find this all-natural vanilla-mint toothpaste as palatable as savory flavors, but those dogs that do are left with fresh, minty breath!

Key Features: 

  • Tea tree oil promotes healthy gums
  • Sweetened with stevia
  • Contains two 2.5-ounce tubes

Cost: $10

KISSABLE All-Natural Dental Care For Small Dogs And Puppies

KISSABLE All-Natural Dental Care For Small Dogs And Puppies

A vanilla and tea tree oil dog toothpaste that’s specifically designed for puppies and small dogs. A small, soft-bristled toothbrush is included.

Key Features: 

  • All-natural tartar control formula
  • Made in the USA
  • Toothbrush and 2.5-ounce tube included

Cost: $13

Oxyfresh Dental No Brush Gel

Oxyfresh Dental No Brush Gel

While you can use this like a regular toothbrush, it can also simply be rubbed into your dog’s gums, which is great for pooches who object to their oral hygiene routine.

Key Features: 

  • Gentle natural formula
  • No scent or taste
  • Come in a 4-ounce package

Cost: $12

Tropiclean Fresh Breath Plaque Remover Clean Teeth Gel

Tropiclean Fresh Breath Plaque Remover Clean Teeth Gel

Similar to the above option, this veterinarian-approved gel is designed to work without brushing, but you can use it as a regular canine toothpaste, too.

Key Features: 

  • Removes plaque and tartar
  • Made with natural ingredients
  • 4-ounce pack

Cost: $11

Other Dog Toothpaste

Bluestem Dog Toothpaste and Toothbrush Kit

Bluestem Dog Toothpaste and Toothbrush

The special dual-headed toothbrush in this dental care kit is designed to quickly brush more of the tooth’s surface, which is ideal for reluctant brushees.

Key Features: 

  • Breaks down biofilm where oral bacteria multiply
  • Chicken flavor
  • 2.5-ounce tube and toothbrush

Cost: $17

GreenJoy Dog Toothpaste

GreenJoy Dog Toothpaste

This beef and herb dog toothpaste comes complete with one double-sided toothbrush and two finger brushes.

Key Features: 

  • Contains natural calcium sources to strengthen teeth
  • Removes plaque and freshens breath
  • Two tubes of toothpaste included in kit

Cost: $13

Ortz Dog Toothpaste and Toothbrush Set

Ortz Dog Toothpaste and Toothbrush Set

The toothpaste itself wouldn’t be out first choice, but the set comes with a two-ended toothbrush and two different types of finger brush, so it’s good if you want to buy everything in one place.

Key Features: 

  • Removes food debris and freshens breath
  • Finger brushes feature expandable openings
  • 1.95-ounce tube

Cost: $12

Petsmile Professional Dog Toothpaste

Petsmile Professional Dog Toothpaste

This professional-grade, Veterinary Oral Health Council-approved dog toothpaste contains Calprox, which is clinically proven to kill bacteria, prevent plaque, beat bad breath, and whiten teeth.

Key Features: 

  • No need to brush, just swipe around mouth with included applicators
  • Palatable rotisserie chicken flavor
  • Comes in a 4.5-ounce package

Cost: $35

SunGrow Dogstory Beef-Flavored Dog Toothpaste

SunGrow Dogstory Beef-Flavored Dog Toothpaste

A complete care canine toothpaste that’s designed with the needs of your dog in mind. Not as effective as some options, but an affordable choice.

Key Features: 

  • Reduces tartar buildups
  • Freshens breath
  • 3.2-ounce tube

Cost: $6

Trixie Mint Toothpaste for Dogs

Trixie Mint Toothpaste for Dogs

If you want your dog’s breath to be as minty fresh as yours is after brushing, this toothpaste is a fine choice.

Key Features: 

  • Cleans teeth and freshens breath
  • Contains calcium-rich bone meal
  • 3.5 ounces

Cost: $8

Well & Good Vanilla Flavored Tartar Control Dog Toothpaste

Well and Good Vanilla Flavored Tartar Control Dog Toothpaste

With its pleasant vanilla flavor, this toothpaste particularly appeals to pups with a sweet tooth, but cleans their teeth rather than given them cavities!

Key Features: 

  • Works on tough tartar buildups
  • Freshens breath
  • 3.25-ounce tubs

Cost: $6

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Lauren Corona