The Best Dog Anxiety Medication

Dogs experience anxiety issues for many reasons, sometimes behavioral and sometimes situational. No matter the cause, there are some steps you can take to help ensure your pet does not suffer with this unpleasant feeling, and anxiety medications are one solution.

Finding the best dog anxiety medication for your pooch means reading reviews, studying product features, and diving into the ins and outs of ingredients and delivery options. With the right dog anxiety medication, your nervous pooch can become a calm, happy and healthy pup. We reviewed dozens of dog anxiety medications to identify the best of the best, based on Amazon reviews, how well they performed in testing, cost, and other considerations. We narrowed our search down to 5 of the top-rated dog anxiety medications pet owners can purchase to ensure a calm and happy pooch.

Top Pick
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Zesty Paws Calming Bites For Dogs

These delicious peanut butter flavored chews help to reduce stress and anxiety in your pet

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$29.97 USD

We’ve identified Zesty Paws Calming Bites For Dogs as the best dog anxiety medication out there. With natural ingredients and a tasty flavor dogs love, this dog anxiety medication is one that will keep your pooch feeling happy and calm. These benefits allow your dog to live their best life, and you to rest easy knowing they aren’t overly stressed out.

The 5 Top-Rated Dog Anxiety Medications

Editor's PicksBrandRating
Best OverallZesty Paws Calming Bites For Dogs3.8
Runner UpVetoquinol Zylkene Behavior Support Capsules4.0
Best Budget BuyVetriScience Laboratories Composure, Calming Support for Dogs3.6
Best Hemp-Based Dog Anxiety MedicationPawlife Calming Treats for Dogs4.2
Best Natural Dog Anxiety MedicationParticular Paws Dog Calming Aid3.6

*Ratings are from Amazon at the time of publication and can change

Our Top Pick: Zesty Paws Calming Bites For Dogs

Zesty Paws Calming Bites For Dogs took the top spot on our list of the best dog anxiety medication, thanks to a list of natural ingredients, soft chew formula suitable for dogs of all ages, and a tasty peanut butter flavor. They contain a blend of organic hemp, chamomile, and  L-Theanine to help naturally calm anxious pets without making them feel drowsy. They are also meant for dogs with aggression and hyperactivity issues.

Those who purchased and reviewed this dog anxiety medication appreciated how quickly these chews worked, with many noticing the effects within about 30 minutes of feeding. Several comments mentioned being skeptical this product would work, but pet owners were very pleasantly surprised with the noticeable effects.

With a price tag of around $30/90 chews, it’s a fairly affordable option, and the quality of the ingredients used in this product, as well as the ease of giving to your pup more than justifies that price. It has a rating of 3.9 on Amazon with more than 2,300 people reviewing it, which we think goes a long way in convincing pet owners to make the investment.

Zesty Paws Calming Treats For Dogs Key Features:

  • Available in a choice of different sized packages
  • Available in a choice of flavors
  • Complementary product line available to help your pet live their healthiest life

Runner-Up: Vetoquinol Zylkene Behavior Support Capsules

Runner Up
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Vetoquinol Zylkene Behavior Support Capsules

An easy-to-administer natural formula that’s lactose- and preservative-free

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$14.50 USD

Vetoquinol Zylkene Behavior Support Capsules took the second place spot on our list of the best dog anxiety medications, and comes in a capsule form, which some dogs might find a little hard to stomach. It is naturally derived from casein (a milk protein) but is lactose-free and preservative-free. Dosing is based on the weight of your dog, which can make it a bit costlier than the other options in our top 5 list, and is best given in advance of the anticipated anxious event.

Those who purchased and reviewed this dog anxiety medication appreciated that this medication was able to help their anxious pets when others had failed, and that it could be used with dogs of various ages, breeds, and sizes.

At a cost of $15/14 capsules, it doesn’t come cheap, especially when you consider that dosing is based on weight. That said, the quality ingredients used in production and the brand recognition for safety more than justifies that price. It has a rating of 4.0 on Amazon with nearly 300 people reviewing it, which we think goes a long way in convincing pet owners to make the investment.

Vetoquinol Zylkene Behavior Support Capsules Key Features:

  • Non-drowsy formula
  • Also suitable for use with cats
  • Safe for long-term use

Best Budget Pick: VetriScience Laboratories Composure, Calming Support for Dogs

Best for Budget
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VetriScience Laboratories Composure

A budget-friendly option packed with scientifically-proven ingredients

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$14.00 USD

VetriScience Laboratories Composure, Calming Support for Dogs is a good choice for those looking for a dog anxiety medication that won’t break the bank. It contains a blend of colostrum, L-theanine and thiamine, which all are recognized for their ability to support calmer behavior and relaxation. Most owners should notice an improvement in their pet’s mood about 30 minutes after dosing, and can expect the effects to last for up to 4 hours. It can be given as needed or as an ongoing supplement.

Those who purchased and reviewed this dog anxiety medication appreciated that these chews were palatable and eaten up quickly by their pups, as well as the science behind the formula. Pet owners used these treats both while traveling and for separation anxiety while at home, and found them to be quite effective.

With a price tag of about $25/60 chews, this dog anxiety medication is a solid choice for those looking for a dog anxiety medication option on a budget. It has a rating of 3.6 on Amazon with more than 2,100 people reviewing it, which we think goes a long way in convincing pet owners that this budget-friendly pick is just as good at calming their pooch as more expensive options.

VetriScience Laboratories Composure, Calming Support for Dogs Key Features:

  • Choice of product sizes available
  • Suitable for dogs of various sizes and weights
  • Veterinarian formulated, and manufactured in the USA

Best Hemp-Based Dog Anxiety Medication: Pawlife Calming Treats for Dogs

Best Hemp-Based Dog Anxiety Medication
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Pawlife Calming Treats for Dogs

Made from organic ingredients with a natural flavor dogs love

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$27.99 USD

Pawlife Calming Treats for Dogs are made with organic chamomile, passion flower, valerian root, and hemp to help provide your canine companion with a sense of calm. They feature a natural duck flavor that dogs love, and are given as a soft chew — making them easy for dogs of all ages and sizes to take.

Those who purchased and reviewed this dog anxiety medication appreciated that their pet was able to get and stay calm for a number of hours with just a single dose of this medication. There were a few customers who felt the product didn’t work for their pet, but said Pawlife customer service was outstanding in taking care of their needs.

At a cost of around $28/120 chews, it’s quite affordable as far as the cost of dog anxiety medication goes, and the quality ingredients, as well as the ease of feeding more than justifies that price. It has a rating of 4.2 on Amazon with more than 400 people reviewing it, which we think goes a long way in convincing pet owners to make the investment.

Pawlife Calming Treats for Dogs Key Features:

  • Ideal for separation anxiety, weather-related woes, or other types of nervous behavior
  • Contains no added fillers
  • Includes a money-back guarantee

Best Natural Dog Anxiety Medication: Particular Paws Dog Calming Aid

Best Natural Dog Anxiety Medication
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Particular Paws Dog Calming Aid

All-natural ingredients in a chewable formula that’s safe for dogs of all ages

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$24.95 USD

Particular Paws Dog Calming Aid is our top pick for those looking for a dog anxiety medication made with natural ingredients, and boasts a blend of melatonin, chamomile flower, passion flower, thiamine mononitrate, and L-tryptophan to help calm pups naturally. It is ideal for use during stressful situations, and as a daily preventative. The time release formula means your pup stays cool as a cucumber all day long.

Those who purchased and reviewed this dog anxiety medication appreciated that their pet stopped barking at every little noise after taking this medication, but that they weren’t knocked out by the calming ingredients. Pet owners said they’ve used this product for everything from routine vet visits to cross-country travel and found it to be effective.

With a price tag of around $25/60 chews, it’s a pretty affordable option, and combined with the natural ingredient list and ease of dosing, the price is more than justified. It has a rating of 3.6 on Amazon with more than 350 people reviewing it, which we think goes a long way in convincing pet owners to make the investment.

Particular Paws Dog Calming Aid Key Features:

  • Chewable formula safe for dogs of all ages and sizes
  • Time release formula
  • Includes a satisfaction guarantee

Who Should Buy a Dog Anxiety Medication

A dog anxiety medication is an ideal choice for those who own a dog that becomes anxious or upset to the point that it is affecting their daily living. A stressed out dog is not a happy dog, and by giving them a small amount of anxiety medication, you can make them much more comfortable. Some dogs are naturally more anxious than others, while some only experience anxiety during high-stress situations such as trips to the vet, thunderstorms, or being left alone for extended periods of time.

While the best dog anxiety medications are given as a prescription from your vet, the supplements in this article contain a blend of less potent ingredients that many pet owners find helpful in calming their pets. Always consult with your veterinarian before giving your pet something new. If you want to avoid medication or you find that medication alone isn’t enough, a dog anxiety vest is another option. Check out our review of the best dog anxiety vests to find the right one for your pup.

Top Pick
Buy Now
Zesty Paws Calming Bites For Dogs

These delicious peanut butter flavored chews help to reduce stress and anxiety in your pet

buy now
$29.97 USD

Important Features to Consider

Not all dog anxiety medications are created equal. A dog anxiety medication should calm your pet without any harmful or irritating side effects. Here’s what to consider when evaluating the options in search of the best anxiety medication for your dog:

  • Ingredients. Look for supplements that contain natural ingredients and those that have been scientifically-proven to help with calming anxiety. Things like valerian, chamomile, and L-tryptophan are all solid ingredients.
  • Formula. Some dog anxiety medications come as capsules, others are given as a soft chew, while others still are liquids that can be directly administered or mixed in with your pet’s food.
  • Size. depending on which product you choose, there will be options when it comes to how many chews or capsules are included, or how much liquid is given. If you have a larger pooch and the medication is dosed by weight, you will want a larger bottle than someone who has a small dog.
  • Price point. Finally, consider how much you are willing to spend on a dog anxiety medication. Dog anxiety medications vary in price from around $20-$50 or more. Keep an eye out for manufacturer’s coupons that can make buying dog anxiety medication more affordable.

Frequently Asked Questions

What is dog anxiety medication and how does it work?

Dog anxiety medication is a medication or supplement that can be given to dogs in order to help with the symptoms of anxiety. It helps to calm and relax your pet so that they can feel relaxed and calm.

What is hemp oil and is it safe for dogs?

Hemp oil is an oil derived from the hemp plant. It is known to have a variety of health benefits, including calming anxiety. While hemp is a type of cannabis plant, it does not contain the psychoactive properties of THC, which is what causes the stereotypical “high” feeling. Hemp is high in a substance called cannabidiol (CBD) which is helpful in treating anxiety in both pets and humans alike. Hemp oil is safe for dogs to consume.

What are the signs of anxiety in dogs?

The signs of anxiety in dogs can include panting, shaking, excessive barking or howling, and aggression. Anxiety can even manifest itself as destructive behaviors, such as chewing, excessive pawing or licking, and soiling where your pet knows they shouldn’t.

Can I give my dog Benadryl for anxiety?

While you can give your dog Benadryl for anxiety, it’s always best to consult with your veterinarian before doing so. The active ingredient in Benadryl, called diphenhydramine, is safe for dogs to ingest, unlike many other cold, sinus, and antihistamine drugs. The medicine helps to make them a little sleepy, which in turn can help calm anxieties.

Other Dog Anxiety Medications We Reviewed

Top Pick
Buy Now
Zesty Paws Calming Bites For Dogs

These delicious peanut butter flavored chews help to reduce stress and anxiety in your pet

buy now
$29.97 USD

We looked at 20 other dog anxiety medications. Even though they didn’t make our 5 best dog anxiety medications list, they’re the best of the rest and each is still a great option for your pet. The information you’ll need to compare each one is included with the listing.

Hemp-Based Dog Anxiety Medication

CALM – Full Spectrum Hemp CBD Oil For Dogs

CALM CBD Dog Hemp Oil

Alleviate your dog’s anxiety, stress, and fear with CALM by CBD Dog Health. The CALM formula combines full spectrum hemp CBD with a blend of MCT oil and lavender essential oil to relax your dog while preventing any potential future ailments. CALM also helps your pet maintain a healthy coat and skin with ingredients like hemp seed oil which has a perfect balance of omega-3 and omega-6 fatty acids.

Key Features:

  • Full spectrum hemp CBD is 100% food grade
  • Reduces stress and anxiety
  • Non-GMO hemp and is pesticide and herbicide free

Cost: $74.99


CBDfx Pet CBD Oil

CBDfx cbd hemp oil

With 150, 300, and 600mg options to choose from, CBDfx Pet CBD Oil is specially formulated for your pet’s size and breed. A simple eyedropper delivery system makes it easy to dose your dog, cat, or other pet, and CBDfx Pet CBD Oil contains less than 0.3% THC, which ensures your pet won’t experience any psychoactive effects. Scientific research suggests that CBD may be an ideal treatment for pet weight loss, anxiety, or pain. Mix CBDfx Pet CBD Oil in with food or apply it directly into your pet’s mouth. Independent lab testing results are available.

Key Features:

  • Full-spectrum CBD oil with terpenes, cannabinoids, and fatty acids for maximum effectiveness
  • Three carefully formulated options for different dog breeds and sizes
  • CO2-extracted and 100% organic with no leftover solvents, pesticides, or fertilizers

Cost: $39.99-$89.99 (depending on dog size)

KING KALM™ 300mg CBD Oil for Pets

King_Kalm_CBD_for_Pets

KING KALM™ 300mg CBD oil for pets is made with only two natural ingredients: high-quality organic CBD and the extremely beneficial krill oil rich in omega-3 fats. Together, these two ingredients work with receptors expressed throughout our body to promote a healthy endocannabinoid system (ECS). The ECS plays a significant role in regulating vital biological functions in mammals such as appetite, sleep cycles, pain sensitivity, and various immune system functions. Like the rest of KING KANINE™ products, their 300mg CBD oil for pets is formulated with your pets in mind by a licensed pharmacist with decades of experience in the industry. Additionally, each formula is tested in third-party laboratories to ensure products meet the highest quality standards and comply with all industry regulations. For best results, consult with a professional veterinarian prior to use.

Key Features:

  • Pharmacist formulated: All our CBD products has been formulated in an ISO 6 clean room by licensed pharmacists with decades of experience.
  • Third Party Lab Tested: Each batch of King Kanine CBD is lab tested to confirm dosage potency, quality, and safety. Lab results and certificates of analysis can be found on the King Kanine website.
  • Natural ingredients: King Kanine pet CBD products are only made with natural and organic ingredients. Our products are free of solvents, pesticides, and other unnatural substances.

Cost: $89.99

Paws of Kerry Calming Treats for Dogs

Paws of Kerry Calming Treats for Dogs

These soft chew treats boast a blend of natural ingredients, including organic hemp oil, L-tryptophan, and organic chamomile. Organic ginger root helps calm nervous stomachs.

Key Features:

  • Made in the USA
  • Non-GMO
  • Made in a FDA-registered factory

Cost: $20

On Point Hemp All Natural Pet Chews

On Point Hemp All Natural Pet Chews

These soft chews contain hemp oil to help ease anxiety, lessen seizures, and provide better joint health, all in a tasty beef and sweet potato flavor.

Key Features:

  • A veteran-owned company
  • Made in the USA
  • Non-GMO

Cost: $35

PremiumCare Calming Treats for Dogs

PremiumCare Calming Treats for Dogs

These natural calming treats have been designed to help alleviate symptoms of dog-related stress and anxiety, and contain a blend of organic hemp and valerian.

Key Features:

  • Includes a money-back guarantee
  • 120-count
  • Contains no added fillers

Cost: $22

Jolly Paws Hemp Oil for Dogs and Cats

Jolly Paws Hemp Oil for Dogs and Cats

This dog anxiety medication features a blend of 100% natural hemp oil in a refreshing peppermint flavor, and is vegan, gluten-free, and has been third-party tested for quality twice.

Key Features:

  • Offers long-lasting results
  • Suitable for use by boths cats and dogs
  • Manufactured in the USA

Cost: $25

Pet Family Choice Hemp Oil

Pet Family Choice Hemp Oil

Made with high-quality organic ingredients, this hemp oil supplement helps to naturally calm and soothe anxious pets. Each bottle provides up to a 120 day supply.

Key Features:

  • Made in the USA
  • Non-GMO
  • Cruelty-free

Cost: $19

POINTPET Stress and Anxiety Relief for Dogs

POINTPET Stress and Anxiety Relief for Dogs

This dog anxiety medication features an easy to administer soft chew formula that contains a blend of natural ingredients including hemp, valerian, and chamomile.

Key Features:

  • Free of corn, wheat, soy, and gluten
  • Certified USDA organic
  • Made in a GMP-compliant facility

Cost: $28

Herbal Supplement for Anxious Dogs

NaturVet Quiet Moments Plus Melatonin

NaturVet Quiet Moments Plus Melatonin

This dog anxiety medication features an easy to administer soft chew formula, and comes with a 100% money-back guarantee.

Key Features:

  • Available in a choice of sizes
  • Wheat-free formula
  • Made in the USA

Cost: $12

ThunderEssence Spray

ThunderEssence Spray

This anxiety medication boasts an easy-to-use spray formula, and contains a blend of all-natural essential oils including lavender, chamomile, and Egyptian geranium to help calm and soothe anxious pets.

Key Features:

  • Veterinarian recommended
  • Available as spray or drops
  • 100% all natural

Cost: $15

Lively Pets Soft Chews for Dogs

Lively Pets Soft Chews for Dogs

This dog anxiety medication features an easy to administer soft chew formula, and contains a blend of all-natural ingredients including chamomile flower, passion flower, ginger root, and L-tryptophan.

Key Features:

  • Made in the USA
  • Money-back guarantee
  • Suitable for dogs aged 6 months and older

Cost: $13

Vet’s Best Comfort Calm Calming Soft Chews

Vet's Best Comfort Calm Calming Soft Chews

This dog anxiety medication features an easy to administer soft chew formula, and has been formulated by veterinarians to support balanced behavior while promoting relaxation with a daily dosing.

Key Features:

  • Available in single or multi-packs
  • Contains no artificial colors of flavors
  • Free of corn, soy, or gluten

Cost: $11

SynergyLabs Richard’s Organics Pet Calm

SynergyLabs Richard’s Organics Pet Calm

This dog anxiety medication features an easy to administer liquid formula, and contains a blend of ingredients including valerian root extract, chamomile, skullcap extract, and passion flower extract.

Key Features:

  • Available in a choice of sizes
  • Suitable for use by both cats and dogs
  • Can be used every 4-6 hours

Cost: $12

BarkBox Veterinarian Formulated Dog Calming Supplement

BarkBox Veterinarian Formulated Dog Calming Supplement

This dog anxiety medication features an easy to administer soft chew formula, and contains a blend of ingredients like tryptophan, lemon balm, and green tea to help calm and relax anxious pets.

Key Features:

  • Made in the USA
  • Veterinarian formulated
  • 110-count

Cost: $25

Drug-Free Dog Anxiety Medication

VetriScience Composure Pro Chews

VetriScience Composure Pro Chews

This dog anxiety medication features an easy to administer soft chew formula, and uses a blend of thiamine, L-tryptophan, colostrum, and L-theanine in an appealing bone shape.

Key Features:

  • Suitable for dogs of all sizes
  • Veterinarian formulated
  • 60-count

Cost: $41

Pet Naturals of Vermont – Calming for Dogs

Pet Naturals of Vermont - Calming for Dogs

This dog anxiety medication features an easy to administer soft chew formula, and contains a blend of L-theanine, colostrum, and thiamine to support a calm state without the use of sedatives.

Key Features:

  • Available in single or multi-packs
  • Contains no wheat, corn, or artificial ingredients
  • 30-count

Cost: $11

Bach Rescue Remedy Pet MegaPACK

Bach Rescue Remedy Pet MegaPACK

This natural anxiety medication boasts a drug-free formula that has been trusted by pet owners for years to help calm nervous and anxious pets using homeopathy.

Key Features:

  • Available in a choice of sizes
  • Alcohol-free formula
  • Suitable for use with cats, dogs, horses, and birds

Cost: $24

Adaptil Calm Home Diffuser for Dogs

Adaptil Calm Home Diffuser for Dogs

If you’re looking for a drug-free option to help calm your anxious dog, this plug-in uses a blend of pheromones that dogs find relaxing and soothing.

Key Features:

  • Lasts up to 30 days
  • Includes a satisfaction guarantee
  • Clinically-proven

Cost: $35

Adaptil Travel Calming Spray for Dogs

Adaptil Travel Calming Spray for Dogs

This drug-free spray has been proven to help fight the symptoms of anxiety in dogs, and takes effect in as little as 5 minutes.

Key Features:

  • Available in a choice of sizes
  • Veterinarian recommended
  • Can be sprayed on your pet’s bedding

Cost: $19

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