The Best Dog Anxiety Medication

Dogs experience anxiety issues for many reasons, sometimes behavioral and sometimes situational. No matter the cause, there are some steps you can take to help ensure your pet does not suffer with this unpleasant feeling, and anxiety medications are one solution.

Finding the best dog anxiety medication for your pooch means reading reviews, studying product features, and diving into the ins and outs of ingredients and delivery options. With the right dog anxiety medication, your nervous pooch can become a calm, happy and healthy pup. We reviewed dozens of dog anxiety medications to identify the best of the best, based on Amazon reviews, how well they performed in testing, cost, and other considerations. We narrowed our search down to 5 of the top-rated dog anxiety medications pet owners can purchase to ensure a calm and happy pooch.

Top Pick
CBDfx Pet CBD Oil

These CBD oil will help to reduce stress and anxiety in your pet.

Check Price

We’ve identified CBDfx Pet CBD Oil as the best dog anxiety medication out there. With its natural ingredients and multi-functional formula, this dog anxiety medication is one that will keep your pooch feeling happy and calm. These benefits allow your dog to live their best life, and you to rest easy knowing they aren’t overly stressed out.

The 5 Top-Rated Dog Anxiety Medications

Editor's PicksBrandRating
Best OverallCBDfx Pet CBD Oil4.9
Runner UpVetoquinol Zylkene Behavior Support Capsules4.0
Best Budget BuyNutri-Vet Pet-Ease Soft Chews4.0
Best Hemp-Based Dog Anxiety TreatJoy Organics Premium CBD Dogs Treats4.5
Best Natural Dog Anxiety MedicationReady Pet Go! Natural Calming Treats for Dogs4.6

*Ratings are from Amazon at the time of publication and can change

Our Top Pick: CBDfx Pet CBD Oil

With 150, 300, and 600mg options to choose from, CBDfx Pet CBD Oil is specially formulated for your pet’s size and breed. A simple eyedropper delivery system makes it easy to dose your dog, cat, or other pet, and CBDfx Pet CBD Oil contains less than 0.3% THC, which ensures your pet won’t experience any psychoactive effects. Scientific research suggests that CBD may be an ideal treatment for pet weight loss, anxiety, or pain. Mix CBDfx Pet CBD Oil in with food or apply it directly into your pet’s mouth. Independent lab testing results are available.

CBDfx Pet CBD Oil Key Features:

  • Full-spectrum CBD oil with terpenes, cannabinoids, and fatty acids for maximum effectiveness
  • Three carefully formulated options for different dog breeds and sizes
  • CO2-extracted and 100% organic with no leftover solvents, pesticides, or fertilizers

Runner-Up: Vetoquinol Zylkene Behavior Support Capsules

Runner Up
Vetoquinol Zylkene Behavior Support Capsules
An easy-to-administer natural formula that’s lactose- and preservative-free

Vetoquinol Zylkene Behavior Support Capsules took the second place spot on our list of the best dog anxiety medications, and comes in a capsule form, which some dogs might find a little hard to stomach. It is naturally derived from casein (a milk protein) but is lactose-free and preservative-free. Dosing is based on the weight of your dog, which can make it a bit costlier than the other options in our top 5 list, and is best given in advance of the anticipated anxious event.

Those who purchased and reviewed this dog anxiety medication appreciated that this medication was able to help their anxious pets when others had failed, and that it could be used with dogs of various ages, breeds, and sizes.

At a cost of $15/14 capsules, it doesn’t come cheap, especially when you consider that dosing is based on weight. That said, the quality ingredients used in production and the brand recognition for safety more than justifies that price. It has a rating of 4.0 on Amazon with nearly 300 people reviewing it.

Vetoquinol Zylkene Behavior Support Capsules Key Features:

  • Non-drowsy formula
  • Also suitable for use with cats
  • Safe for long-term use

Best Budget Pick: Nutri-Vet Pet-Ease Soft Chews

Best for Budget
Nutri-Vet Pet-Ease Soft Chews
A budget-friendly option packed tasty, high-quality natural ingredients

Nutri-Vet Pet-Ease Soft Chews are an excellent choice for those looking for a dog anxiety medication that won’t break the bank. Each packet contains 70 soft chews that are made with chamomile and tryptophan to soothe your dog’s anxiety naturally. These veterinary-formulated soft chews are suitable for dogs of all sizes and have a tasty natural hickory smoke flavor your dog is sure to look forward to each time. 

Most dog owners who purchased and reviewed this dog anxiety medication expressed their relief that they actually work! Just have a peek at the reviews yourself to see that dog owners have commented that they “worked wonders” and “work like a charm”. One even called them “life changing.”

With a price tag of only $3/70 soft chews, this dog anxiety medication is unbelievably affordable. It’s a solid choice for those looking for a dog anxiety medication option on a budget. It has a rating of 4.0 on Amazon, which shows that this budget-friendly pick is just as good at calming their pooch as more expensive options.

Nutri-Vet Pet-Ease Soft Chews Key Features:

  • Natural hickory smoke flavor
  • For dogs of all sizes
  • 70 count

Best Hemp-Based Dog Anxiety Treats: Joy Organics Premium CBD Dogs Treats

Best Hemp-Based Dog Anxiety Treats
Joy Organics Premium CBD Dog Treats

Made from organic ingredients with a natural flavor dogs love.

Check Price

Joy Organics Premium CBD Dog Treats are made with organic sweet potato, sunflower, vitamin e, and hemp to help provide your canine companion with a sense of calm. They feature a natural beef flavor that dogs love, and are given as a soft chew — making them easy for dogs of all ages and sizes to take.

There were a few customers who said the Joy Organics customer service was outstanding in taking care of their needs. Joy Organics is a family founded company that’s managed by Joy’s family.

At a cost of around $35/30 chews, it’s quite affordable as far as the cost of dog anxiety medication goes, and the quality ingredients, as well as the ease of feeding, more than justifies that price. It has a rating of 4.5 stars, which we think goes a long way in convincing pet owners to make the investment.

Joy Organics Premium CBD Dog Treats Key Features:

  • Ideal for separation anxiety, weather-related woes, or other types of nervous behavior
  • Beef flavored
  • Money-back guarantee

Best Natural Dog Anxiety Medication: Ready Pet Go! Natural Calming Treats for Dogs

Best Natural Dog Anxiety Medication
Ready Pet Go! Natural Calming Treats for Dogs
All-natural ingredients and a tasty bacon and cheese flavor make this natural option a must-buy for dogs suffering from anxiety

Ready Pet Go! Natural Calming Treats for Dogs is our recommended pick if you’re looking for a dog anxiety medication that is made with natural ingredients your dog won’t turn those nose up at. The ingredient list of these USA-made chews includes thiamine and chamomile, as well as essential amino acids and soothing herbs. And how could we not mention its scrumptious bacon and cheese flavor? 

Ready Pet Go!’s chews are ideal to give your four-legged friend whenever they’re experiencing a stressful situation, such as storms of vet visits. Those who purchased and reviewed this dog anxiety medication appreciated that it helped to calm their dogs even when nothing else helped. 

With a price tag of around $26/90 chews, it’s quite an affordable option. It has a rating of 4.6 on Amazon with more than 400 people reviewing it. Be sure to give it a try if you want to provide your dog with a natural dose of relief from their anxiety. 

Ready Pet Go! Natural Calming Treats for Dogs Key Features:

  • 90 chews
  • Natural ingredients including amino acids
  • Delicious bacon and cheese flavor

Who Should Buy a Dog Anxiety Medication

A dog anxiety medication is an ideal choice for those who own a dog that becomes anxious or upset to the point that it is affecting their daily living. A stressed out dog is not a happy dog, and by giving them a small amount of anxiety medication, you can make them much more comfortable. Some dogs are naturally more anxious than others, while some only experience anxiety during high-stress situations such as trips to the vet, thunderstorms, or being left alone for extended periods of time.

While the best dog anxiety medications are given as a prescription from your vet, the supplements in this article contain a blend of less potent ingredients that many pet owners find helpful in calming their pets. Always consult with your veterinarian before giving your pet something new. If you want to avoid medication or you find that medication alone isn’t enough, a dog anxiety vest is another option. Check out our review of the best dog anxiety vests to find the right one for your pup.

Top Pick
CBDfx Pet CBD Oil

These CBD oil will help to reduce stress and anxiety in your pet.

Check Price

Important Features to Consider

Not all dog anxiety medications are created equal. A dog anxiety medication should calm your pet without any harmful or irritating side effects. Here’s what to consider when evaluating the options in search of the best anxiety medication for your dog:

  • Ingredients. Look for supplements that contain natural ingredients and those that have been scientifically-proven to help with calming anxiety. Things like valerian, chamomile, and L-tryptophan are all solid ingredients.
  • Formula. Some dog anxiety medications come as capsules, others are given as a soft chew, while others still are liquids that can be directly administered or mixed in with your pet’s food.
  • Size. depending on which product you choose, there will be options when it comes to how many chews or capsules are included, or how much liquid is given. If you have a larger pooch and the medication is dosed by weight, you will want a larger bottle than someone who has a small dog.
  • Price point. Finally, consider how much you are willing to spend on a dog anxiety medication. Dog anxiety medications vary in price from around $20-$50 or more. Keep an eye out for manufacturer’s coupons that can make buying dog anxiety medication more affordable.

Frequently Asked Questions

What is dog anxiety medication and how does it work?

Dog anxiety medication is a medication or supplement that can be given to dogs in order to help with the symptoms of anxiety. It helps to calm and relax your pet so that they can feel relaxed and calm.

What is hemp oil and is it safe for dogs?

Hemp oil is an oil derived from the hemp plant. It is known to have a variety of health benefits, including calming anxiety. While hemp is a type of cannabis plant, it does not contain the psychoactive properties of THC, which is what causes the stereotypical “high” feeling. Hemp is high in a substance called cannabidiol (CBD) which is helpful in treating anxiety in both pets and humans alike. Hemp oil is safe for dogs to consume.

What are the signs of anxiety in dogs?

The signs of anxiety in dogs can include panting, shaking, excessive barking or howling, and aggression. Anxiety can even manifest itself as destructive behaviors, such as chewing, excessive pawing or licking, and soiling where your pet knows they shouldn’t.

Can I give my dog Benadryl for anxiety?

While you can give your dog Benadryl for anxiety, it’s always best to consult with your veterinarian before doing so. The active ingredient in Benadryl, called diphenhydramine, is safe for dogs to ingest, unlike many other cold, sinus, and antihistamine drugs. The medicine helps to make them a little sleepy, which in turn can help calm anxieties.

Other Dog Anxiety Medications We Reviewed

Top Pick
CBDfx Pet CBD Oil

These CBD oil will help to reduce stress and anxiety in your pet.

Check Price

We looked at 20 other dog anxiety medications. Even though they didn’t make our 5 best dog anxiety medications list, they’re the best of the rest and each is still a great option for your pet. The information you’ll need to compare each one is included with the listing.

Hemp-Based Dog Anxiety Medication

Petly Pet Hemp CBD Dog Treats

Petly CBD Pet Treats

These soft chews contain organically-grown broad spectrum hemp to help ease anxiety, lessen seizures, and provide better joint health, all in a tasty beef flavor. Don’t forget to use their discount code PL20 to get 20% off your purchase!

Key Features:

  • Veterinarian Formulated
  • 25 chews
  • Made in USA

Cost: $29.99

Receptra Pet Tincture

Receptra Pet Tincture

This dog anxiety supplement features full spectrum hemp extract and is all natural and organic. It contains only two simple ingredients and a 30 day satisfaction guarantee.

Key Features:

  • Offers recovery and relief from anxious situations
  • Suitable for both cats and dogs
  • Suitable for small pets

Cost: $45

RE Botanicals Hemp CBD Tincture for Pets

RE Botanicals Hemp CBD Tincture for Pets

Made with high-quality US grown organic ingredients, this hemp oil supplement helps to naturally calm and soothe anxious pets. RE Botanicals even claims that: 1% of RE Botanicals sales are donated to regenerative agriculture and helping farmers create healthier soils.

Key Features:

  • USDA Certified Organic Hemp 
  • Third party lab tested
  • Non-GMO and no added preservatives or chemicals

Cost: $19


Mighty Petz MAX Hemp Calming Treats for Dogs

Mighty Petz MAX Hemp Calming Treats for Dogs

A natural and tasty way to alleviate anxiety and support stress levels in canines. Features hemp oil and melatonin + 7 natural calming ingredients.

Key Features:

  • Veterinarian formulated with 9 natural calming ingredients
  • 100 cheese-flavored chews (low allergen & low calorie)
  • 100% satisfaction guarantee

Cost: $29.98

CALM – Full Spectrum Hemp CBD Oil For Dogs

CALM CBD Dog Hemp Oil

Alleviate your dog’s anxiety, stress, and fear with CALM by CBD Dog Health. The CALM formula combines full spectrum hemp CBD with a blend of MCT oil and lavender essential oil to relax your dog while preventing any potential future ailments. CALM also helps your pet maintain a healthy coat and skin with ingredients like hemp seed oil which has a perfect balance of omega-3 and omega-6 fatty acids.

Key Features:

  • Full spectrum hemp CBD is 100% food grade
  • Reduces stress and anxiety
  • Non-GMO hemp and is pesticide and herbicide free

Cost: $74.99

KING KALM™ 300mg CBD Oil for Pets

King_Kalm_CBD_for_Pets

KING KALM™ 300mg CBD oil for pets is made with only two natural ingredients: high-quality organic CBD and the extremely beneficial krill oil rich in omega-3 fats. Together, these two ingredients work with receptors expressed throughout our body to promote a healthy endocannabinoid system (ECS). The ECS plays a significant role in regulating vital biological functions in mammals such as appetite, sleep cycles, pain sensitivity, and various immune system functions. Like the rest of KING KANINE™ products, their 300mg CBD oil for pets is formulated with your pets in mind by a licensed pharmacist with decades of experience in the industry. Additionally, each formula is tested in third-party laboratories to ensure products meet the highest quality standards and comply with all industry regulations. For best results, consult with a professional veterinarian prior to use.

Key Features:

  • Pharmacist formulated: All our CBD products has been formulated in an ISO 6 clean room by licensed pharmacists with decades of experience.
  • Third Party Lab Tested: Each batch of King Kanine CBD is lab tested to confirm dosage potency, quality, and safety. Lab results and certificates of analysis can be found on the King Kanine website.
  • Natural ingredients: King Kanine pet CBD products are only made with natural and organic ingredients. Our products are free of solvents, pesticides, and other unnatural substances.

Cost: $89.99

Paws of Kerry Calming Treats for Dogs

Paws of Kerry Calming Treats for Dogs

These soft chew treats boast a blend of natural ingredients, including organic hemp oil, L-tryptophan, and organic chamomile. Organic ginger root helps calm nervous stomachs.

Key Features:

  • Made in the USA
  • Non-GMO
  • Made in a FDA-registered factory

Cost: $20

PremiumCare Calming Treats for Dogs

PremiumCare Calming Treats for Dogs

These natural calming treats have been designed to help alleviate symptoms of dog-related stress and anxiety, and contain a blend of organic hemp and valerian.

Key Features:

  • Includes a money-back guarantee
  • 120-count
  • Contains no added fillers

Cost: $22

POINTPET Stress and Anxiety Relief for Dogs

POINTPET Stress and Anxiety Relief for Dogs

This dog anxiety medication features an easy to administer soft chew formula that contains a blend of natural ingredients including hemp, valerian, and chamomile.

Key Features:

  • Free of corn, wheat, soy, and gluten
  • Certified USDA organic
  • Made in a GMP-compliant facility

Cost: $28

Herbal Supplement for Anxious Dogs

NaturVet Quiet Moments Plus Melatonin

NaturVet Quiet Moments Plus Melatonin

This dog anxiety medication features an easy to administer soft chew formula, and comes with a 100% money-back guarantee.

Key Features:

  • Available in a choice of sizes
  • Wheat-free formula
  • Made in the USA

Cost: $12

ThunderEssence Spray

ThunderEssence Spray

This anxiety medication boasts an easy-to-use spray formula, and contains a blend of all-natural essential oils including lavender, chamomile, and Egyptian geranium to help calm and soothe anxious pets.

Key Features:

  • Veterinarian recommended
  • Available as spray or drops
  • 100% all natural

Cost: $15

Lively Pets Soft Chews for Dogs

Lively Pets Soft Chews for Dogs

This dog anxiety medication features an easy to administer soft chew formula, and contains a blend of all-natural ingredients including chamomile flower, passion flower, ginger root, and L-tryptophan.

Key Features:

  • Made in the USA
  • Money-back guarantee
  • Suitable for dogs aged 6 months and older

Cost: $13

Vet’s Best Comfort Calm Calming Soft Chews

Vet's Best Comfort Calm Calming Soft Chews

This dog anxiety medication features an easy to administer soft chew formula, and has been formulated by veterinarians to support balanced behavior while promoting relaxation with a daily dosing.

Key Features:

  • Available in single or multi-packs
  • Contains no artificial colors of flavors
  • Free of corn, soy, or gluten

Cost: $11

SynergyLabs Richard’s Organics Pet Calm

SynergyLabs Richard’s Organics Pet Calm

This dog anxiety medication features an easy to administer liquid formula, and contains a blend of ingredients including valerian root extract, chamomile, skullcap extract, and passion flower extract.

Key Features:

  • Available in a choice of sizes
  • Suitable for use by both cats and dogs
  • Can be used every 4-6 hours

Cost: $12

BarkBox Veterinarian Formulated Dog Calming Supplement

BarkBox Veterinarian Formulated Dog Calming Supplement

This dog anxiety medication features an easy to administer soft chew formula, and contains a blend of ingredients like tryptophan, lemon balm, and green tea to help calm and relax anxious pets.

Key Features:

  • Made in the USA
  • Veterinarian formulated
  • 110-count

Cost: $25

Drug-Free Dog Anxiety Medication

VetriScience Composure Pro Chews

VetriScience Composure Pro Chews

This dog anxiety medication features an easy to administer soft chew formula, and uses a blend of thiamine, L-tryptophan, colostrum, and L-theanine in an appealing bone shape.

Key Features:

  • Suitable for dogs of all sizes
  • Veterinarian formulated
  • 60-count

Cost: $41

Pet Naturals of Vermont – Calming for Dogs

Pet Naturals of Vermont - Calming for Dogs

This dog anxiety medication features an easy to administer soft chew formula, and contains a blend of L-theanine, colostrum, and thiamine to support a calm state without the use of sedatives.

Key Features:

  • Available in single or multi-packs
  • Contains no wheat, corn, or artificial ingredients
  • 30-count

Cost: $11

Bach Rescue Remedy Pet MegaPACK

Bach Rescue Remedy Pet MegaPACK

This natural anxiety medication boasts a drug-free formula that has been trusted by pet owners for years to help calm nervous and anxious pets using homeopathy.

Key Features:

  • Available in a choice of sizes
  • Alcohol-free formula
  • Suitable for use with cats, dogs, horses, and birds

Cost: $24

Adaptil Calm Home Diffuser for Dogs

Adaptil Calm Home Diffuser for Dogs

If you’re looking for a drug-free option to help calm your anxious dog, this plug-in uses a blend of pheromones that dogs find relaxing and soothing.

Key Features:

  • Lasts up to 30 days
  • Includes a satisfaction guarantee
  • Clinically-proven

Cost: $35

Adaptil Travel Calming Spray for Dogs

Adaptil Travel Calming Spray for Dogs

This drug-free spray has been proven to help fight the symptoms of anxiety in dogs, and takes effect in as little as 5 minutes.

Key Features:

  • Available in a choice of sizes
  • Veterinarian recommended
  • Can be sprayed on your pet’s bedding

Cost: $19

Avatar